By J. M. G. Wilson (auth.), Andrew W. Bruce FRCS, FRCS(C), John Trachtenberg MD, FRCS(C) (eds.)
Carcinoma of the prostate more and more dominates the eye of urologists for either medical and medical purposes. the hunt for a proof and the prediction of the variable behaviour of the malignant prostatic phone keeps unabated. the quest for extra designated tumour staging and more beneficial remedy is both lively. Editors Andrew Bruce and John Trachtenberg have assembled said leaders in prostate melanoma to provide these components of direct curiosity to the clinician. there are many different issues that may were thought of yet each one of these, reminiscent of experimental tumour types or biochemical components affecting telephone progress, nonetheless lack fast program for the clinician. Carcinoma of the prostate keeps to have its optimum occurrence within the western international, and the variation compared to the occurrence within the a ways East seems to be actual and never masked by means of diagnostic or different elements. a couple of different epidemiological features desire cautious research: Is the prevalence expanding? Is the survival bettering? Is the analysis worse within the more youthful sufferer? Epidemiological facts are simply misused and misinterpreted in order that an actual research of the recognized proof makes a massive commencing bankruptcy to this book.
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1974). There had been no independent evaluation. Is the Gleason System Readily Learned, as Claimed by the NPCP? Gleason reported his observations in 1966. Although this was followed by several reports by Gleason and Mellinger, both of the Veterans Administration (Gleason 1966, 1977; Gleason et al. 1974; Mellinger et al. 1967; Mellinger1977) , the system was not readily a~cepted by pathologists. The only other report in the literature on the system was by Harada et al. (1977) . These authors found it necessary to have two tutorials by Gleason before they felt reasonably competent to use the system.
It seems probable that the condition is multifactorial. The wide differences in incidence recorded in different ethnic groups, and in the same ethnic groups both within and between countries, perhaps provide some of the most promising clues. The positive relationship between dietary fat on the one hand, and the negative association with green and yellow vegetables and carotene intake on the other, seem tantalizingly close to a causal connection. Further work in this field, as well as on hormonal relationships, may throw a clearer light on the etiology of cancer of the prostate and then, perhaps, on the way to prevent it developing.
There were only two cases of localized disease (stage B) diagnosed among the 26 men under 50. The authors concluded that the main reason for their findings of such a poor outcome in younger men was late diagnosis due to failure to consider the possibility of prostatic cancer at this age. But they also concluded that cancers in younger men have a greater force of malignancy (Rosenberg's "virulence"), as evidenced by the much poorer survival even at the same clinical stage of the disease, when compared with older men.